Disease: Familial Alzheimer Disease (FAD)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
TREM2 Q9NZC2 triggering receptor expressed on myeloid cells 2 3.3E-09 0.519 0.769
TOMM40 O96008 translocase of outer mitochondrial membrane 40 Transporter 0.99 0.590 0.538
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962
SUMO1 P63165 small ubiquitin like modifier 1 0.86 0.533 0.731
SUCLA2 Q9P2R7 succinate-CoA ligase ADP-forming subunit beta Enzyme 2.3E-03 0.566 0.654
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885
PYY P10082 peptide YY Signaling 1.2E-02 0.588 0.615
PSEN2 P49810 presenilin 2 Enzyme 5.4E-04 0.550 0.654
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923
PICALM Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 1.00 0.592 0.538
NRGN Q92686 neurogranin 0.48 0.608 0.615
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846
NOTCH3 Q9UM47 notch receptor 3 0.41 0.435 0.808
NEFL P07196 neurofilament light 0.488 0.769
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
MAPK8 P45983 mitogen-activated protein kinase 8 Kinase 1.00 0.397 0.885
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885
LEP P41159 leptin 0.46 0.349 0.846
LAMC2 Q13753 laminin subunit gamma 2 Enzyme modulator 2.9E-12 0.389 0.923
ITM2B Q9Y287 integral membrane protein 2B 0.63 0.617 0.654
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846